Radiation-induced Adaptive Response: New Potential for Cancer Treatment

micrornas: promising potential targets for cancer treatment

Adaptive Radiation for Lung Cancer

The challenges of lung cancer radiotherapy are intra/inter-fraction tumor/organ anatomy/motion changes and the need to spare surrounding critical structures. Evolving radiotherapy technologies, such as four-dimensional (4D) image-based motion management, daily on-board imaging and adaptive radiotherapy based on volumetric images over the course of radiotherapy, have enabled us to deliver higher...

Treatment of radiation-induced normal tissue lesions

Radiation treatment planning for prostate cancer: A new dosimetric comparison of five and seven fields IMRT plans

Background: To compare the dosimetric coverage of the planning target volume (PTV) and the dose delivered to the main Organs at Risk (OARs) in 5 and 7-field techniques of Intensity Modulated Radiation Therapy (IMRT) in patients with local prostate cancer. Materials and Methods: Twelve patients with local prostate cancer underwent 5 and 7-field IMRT planning. The delivery of IMRT was carried out...

A new view of radiation-induced cancer.

Biologically motivated mathematical models are important for understanding the mechanisms of radiation-induced carcinogenesis. Existing models fall into two categories: (1) short-term formalisms, which focus on the processes taking place during and shortly after irradiation (effects of dose, radiation quality, dose rate and fractionation), and (2) long-term formalisms, which track background ca...